Gamma Glutamylcysteine Synthetase (GCS) / Glutamate-cysteine Ligase Ab-1

Antibodies

Gamma Glutamylcysteine Synthetase (GCS) / Glutamate-cysteine Ligase Ab-1

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Compare different antibodies against Gamma Glutamylcysteine Synthetase.

Rabbit Polyclonal Antibody

Description: Glutathione (GSH) plays an important role in detoxification of oxidants and toxins from the cells. In most cells GSH is synthesized de novo in two steps catalysed by Gamma Glutamylcysteine Synthetase (GCS) / Glutamate-cystein Ligase and GSH synthetase. GCS catalyses the first and rate limiting step and is important in GSH homeostasis. It is composed of two subunits: heavy and light. These subunits are coded by different genes which are controlle by different mechanisms. The heavy subunit carries the catalytic activity and can be inhibited through feedback mechanism by GSH. Binding of light subunit to heavy subunit reduces the Michaelis-Menten constant for glutamate to a physiological concentration of 1.2mM and increases the inhibitory constant for GSH.

Comments: Ab-1 recognizes the heavy subunit of GCS.

IgIsotype: IgG

Epitope: aa 295-313

Immunogen: A synthetic peptide derived from corresponding to aa 295-313 of rat GCLC (heavy subunit of GCS).

Positive Control:Jurkat, MAD109, PC12 cells

Cellular Localization:Cytoplasmic

Molecular Weight:73kDa

Species reactivity:Human, Monkey, Mouse, and Rat, Cow (weak). Others not known.

Please select from the items below to add to your shopping cart:

	Cat. # RB-1697 - P
	( 1.0ml at 1.0mg/ml) ( Purified Ab with BSA and Azide)
	Cat. # RB-1697 - P1
	( 0.5ml at 1.0mg/ml) ( Purified Ab with BSA and Azide)
	Cat. # RB-1697 - PCL
	( 0.1ml at 250ug/0.1ml) ( Positive Control for Western Blot)
	Cat. # RB-1697 - P1ABX
	( 0.5ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # RB-1697 - PABX
	( 1.0 ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # RB-1697 - P0
	( 0.1ml at 1.0mg/ml) ( Purified Ab with BSA and Azide)