Grb2 / sem5 / ASH Signalling Protein Ab-4

Antibodies

Grb2 / sem5 / ASH Signalling Protein Ab-4

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Compare different antibodies against Grb2.

Mouse Monoclonal Antibody

Description: Grb2 protein contains one SH2 domain flanked on both sides by an SH3 domain. Ab-1 binds to the junction between the amino terminal SH3 domain and the SH2 domain of Grb2. Reactivity with Grb2 deletion mutants suggests that its epitope maps between aa 54-62. In response to EGF, Grb2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The Grb2-Sos complex then binds the EGF-receptor. These interactions play a critical role in the activation of the p21^ras signalling pathway.

IgIsotype: IgG1 / kappa

Epitope: aa 54-62

Clone Designation: 2GB04 ; same as C1.4

Immunogen: Purified recombinant human Grb2 protein.

Positive Control:HeLa cells. Tonsil.

Cellular Localization:Cytoplasmic

Molecular Weight:24-25kDa

Species reactivity:Human, Cow, Mouse, Rat, and Xenopus. Others-not known.

Please select from the items below to add to your shopping cart:

	Cat. # MS-1457 - P1
	( 0.5ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1457 - P0
	( 0.1ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1457 - PCS
	( Positive Control for Histology, a set of 5 slides)
	Cat. # MS-1457 - R7
	( 7.0ml ) ( Ready-to-use for Immunohistochemical Staining)
	Cat. # MS-1457 - PABX
	( 0.2ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # MS-1457 - P
	( 1.0ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1457 - P1ABX
	( 0.1ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)

Formalin-fixed, paraffin-embedded human tonsil stained with NeoMarkers' Grb2 Ab-4 (Cat. #MS-1457-P) using peroxidase-conjugate and AEC chromogen. Note nuclear and cytoplasmic staining of cell.