SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1

Antibodies

SREBP-1 (Sterol Regulatory Element Binding Protein-1) Ab-1

Click here to view datasheet for research use

Click here to view PCL datasheet

Compare different antibodies against SREBP-1.

Mouse Monoclonal Antibody

Description: SREBP-1 and –2 are transcription factors which participate in the control of cholesterol homeostasis. SREBPs proteins, which are attached to the endoplasmic reticulum and nuclear envelope, are proteolytically cleaved and thus activated in response to conditions of low cellular sterol. Upon activation of SREBP-1 or –2, an ~480-500 amino acid, N-terminal cleavage fragment of these proteins enters the nucleus and activates transcription of enzymes and other proteins required for cholesterol synthesis. SCA (SREBP-cleavage activity) and caspase-3 proteases cleave SREBPs. SREBP proteins containing point mutations at caspase-3 cleavage sites (Asp460 in SREBP-1 and Asp468 in SREBP-2) do not become cleaved following induction of apoptosis, suggesting that SREBPs may play some role in apoptotic processes.

IgIsotype: IgG1 / kappa

Epitope: aa 301-407

Clone Designation: 2A4

Immunogen: Recombinant protein encoding N-terminal amino acids 301-407 (the bHLH/leucine zipper domain) of human SREBP-1.

Positive Control:HeLa and IMR5 cells

Cellular Localization:Cytoplasmic and nuclear

Molecular Weight:125kDa (precursor) and 60-70kDa (cleaved)

Species reactivity:Human and Hamster. Others not-known.

Please select from the items below to add to your shopping cart:

	Cat. # MS-1207 - P0
	( 0.1ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1207 - P1
	( 0.5ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1207 - P
	( 1.0ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-1207 - P1ABX
	( 0.1ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # MS-1207 - PABX
	( 0.2ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # MS-1207 - PCL
	( 0.1ml at 250ug/0.1ml) ( Positive Control for Western Blot)