Retinoblastoma (Rb) Ab-1

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Antibodies

Retinoblastoma (Rb) Ab-1

Click here to view datasheet for research use

Click here to view PCL datasheet

Compare different antibodies against Retinoblastoma.

Mouse Monoclonal Antibody

Description: Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Comments: Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein. It shows no cross reaction with p107 and p130.

IgIsotype: IgG1

Epitope: aa703-722

Clone Designation: 1F8 ;same as Rb1

Immunogen: Recombinant human Rb protein

Positive Control:Ls174T, HT29, HUVEC cells. Normal colon , Breast CA and colon CA.

Cellular Localization:Nuclear

Molecular Weight:105kDa

Species reactivity:Human. Does not react with mouse and rat. Others-not known.

Please select from the items below to add to your shopping cart:

	Cat. # MS-107 - B0
	( 0.1ml at 200ug/ml) ( Biotin labeled Ab with BSA and Azide)
	Cat. # MS-107 - P1
	( 0.5ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-107 - PCS
	( Positive Control for Histology, a set of 5 slides)
	Cat. # MS-107 - PCL
	( 0.1ml at 250ug/0.1ml) ( Positive Control for Western Blot)
	Cat. # MS-107 - B
	( 1.0ml at 200ug/ml) ( Biotin labeled Ab with BSA and Azide)
	Cat. # MS-107 - B1
	( 0.5ml at 200ug/ml) ( Biotin labeled Ab with BSA and Azide)
	Cat. # MS-107 - PABX
	( 0.2ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)
	Cat. # MS-107 - R7
	( 7.0ml ) ( Ready-to-use for Immunohistochemical Staining)
	Cat. # MS-107 - P
	( 1.0ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-107 - P0
	( 0.1ml at 200ug/ml) ( Purified Ab with BSA and Azide)
	Cat. # MS-107 - P1ABX
	( 0.1ml at 1.0mg/ml) ( Purified Ab without BSA and Azide)

Formalin-fixed, paraffin-embedded human breast carcinoma stained with NeoMarkers' Retinoblastoma (Rb) Ab-1 (Cat. #MS-107-P) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of tumor cells.