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Heat Shock Factor 1 (HSF1) Ab-1
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Compare different antibodies against Heat Shock Factor 1.
Rat Monoclonal Antibody
Description: HSF1 responds to cellular stress signals such as heat, heavy metals, and oxidative reagents; binds to heat shock response elements (HSEs) in the upstream region of heat shock gene and activates their transcription. Some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA.
IgIsotype: IgG1
Epitope: aa 425-439 of mouse HSF1
Clone Designation: 4B4
Immunogen: Recombinant mouse HSF1 protein (aa1-503).
Positive Control:LS174T or MAD109 cells
Cellular Localization:Nuclear
Molecular Weight:70-85kDa (depending upon the source and state of cells)
Species reactivity:Human, Mouse, and Rat. Others not known.
  
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