Rabbit Monoclonal Antibodies

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Antibodies

Alphabetical List of Antibodies

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FEATURED ANTIBODY:
Epidermal Growth Factor Receptor (EGFR, Clone EP38Y)

 

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Rabbit Monoclonal Antibody

Description: EGFR is a type I receptor tyrosine kinase with sequence homology to c-erbB1, B2, B3, B4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, colon, lung, stomach, head&neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.

Epitope: not determined

Clone Designation: EP38Y

Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGFR

Positive Control:Squamous carcinoma

Molecular Weight:175kDa

Species reactivity:Human. Others not tested.

Cellular Localization:Cell membrane and occasional cytoplasmic


Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with rabbit monoclonal anti-Epidermal Growth Factor Receptor antibody (EGFR) (Cat. #RM-2111-S) using peroxidase-conjugate and DAB chromogen. Note membrane staining of tumor cells.



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