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Rabbit Monoclonal Antibody
Description: EGFR is a type I receptor tyrosine kinase with sequence homology to c-erbB1, B2, B3, B4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-alpha (TGF-alpha), Heparin-binding EGF (HB-EGF), amphiregulin, betacellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, colon, lung, stomach, head&neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.
Epitope: not determined
Clone Designation:
EP38Y
Immunogen: A synthetic phospho-peptide corresponding to residues surrounding Tyr1068 of human EGFR
Positive Control:Squamous carcinoma
Molecular Weight:175kDa
Species reactivity:Human. Others not tested.
Cellular Localization:Cell membrane and occasional cytoplasmic
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Formalin-fixed, paraffin-embedded human squamous cell carcinoma stained with rabbit monoclonal anti-Epidermal Growth Factor Receptor antibody (EGFR) (Cat. #RM-2111-S) using peroxidase-conjugate and DAB chromogen. Note membrane staining of tumor cells.
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