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Keratin, Pan Ab-3
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Compare different antibodies against Keratin, Pan.
Mouse Monoclonal Antibody
Description: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI <5.7) and basic (pI >6.0) subfamilies. Members of the acidic and basic subfamilies are found together in pairs. The composition of keratin pairs varies with the epithelial cell type, stage of differentiation, cellular growth environment, and disease state. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis.
Comments: Ab-3 recognizes the keratins of acidic as well as basic subfamilies. It reacts with keratinized and corneal epidermis, stratified squamous epithelia of internal organs, stratified epithelia, hyperproliferative keratinocytes, and simple epithelia. Ab-3 is a broad spectrum anti pan-keratin antibody, which differentiates epithelial from non-epithelial tumors. Unlike AE1/AE3 pan-keratin antibody, Lu-5 works well with pepsin digestion of formalin-fixed tissues.
IgIsotype: IgG1
Epitope: Not determined
Clone Designation: Lu-5
Immunogen: Lung cancer cell line
Positive Control:Skin or squamous cell CA
Cellular Localization:Cytoplasmic
Species reactivity:Human, Cow, Rat, Chicken, Snake, and Frog. Shows a very wide reactivity in vertebrates.
   
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Formalin-fixed, paraffin-embedded human squamous cell carcinoma of lung stained with NeoMarkers' Keratin, Pan Ab-3 (Cat. #MS-744-A) using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of tumor cells.
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