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Vinculin Ab-1
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Compare different antibodies against Vinculin.
Mouse Monoclonal Antibody
Description: Vinculin is an attachment protein involved in the indirect binding of intracellular actin filaments to extracellular fibronectin. Vinculin binds to actin capping protein and alpha actinin, which in turn binds to actin. The binding of fibronectin is also indirect where vinculin binds to talin, which in turn binds to the intracellular domain of the fibronectin receptor which itself is the ligand for fibronectin. Vinculin is widely distributed in tissue and is expressed where smooth muscle actin and fibroblasts attach to the extracellular matrix.
Comments: Ab-1 is useful for studies of vinculin in platelet activation.
IgIsotype: IgG
Epitope: Not determined
Clone Designation: VLN01
Immunogen: Semi-purified vinculin
Positive Control:HeLa cells. Skin
Cellular Localization:Cell membrane and cytoplasmic
Molecular Weight:130kDa (vinculin) and 150kDa (meta-vinculin)
Species reactivity:Human. Others not-known.
  
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